rodA [2017-12-20 11:31:50]

SEDS family peptidoglycan glycosyltransferase, control of cell shape and elongation

Locus: BSU38120

Isoelectric point: 8.76

Molecular weight: 43.12 kDa

Protein length: 393 aa

Gene length: 1179 bp

Function: control of cell shape and elongation

Product: SEDS family peptidoglycan glycosyltransferase

Essential: yes

Synonyms: ywcF, ipa-42d

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell shape
• Lifestyles → Coping with stress → Cell envelope stress proteins (controlled by SigM, V, W, X, Y)
• Groups of genes → Essential genes
• Groups of genes → Membrane proteins

Gene

Coordinates: 3,912,332 → 3,913,513

Phenotypes of a mutant

• essential PubMed
• CRISPRi knockdown mutant has a terminal phenotype of severe lysis PubMed

The protein

Catalyzed reaction/ biological activity

• principal peptidoglycan glycosyltransferase of the elongasome PubMed

Protein family

• FtsW/RodA/SpoVE family (according to Swiss-Prot)
• SEDS proteins (shape, elongation, division, and sporulation) PubMed

Paralogous protein(s)

• FtsW, SpoVE

Localization

• integral membrane protein PubMed
• forms circumferentially moving patches PubMed
• localization depends on MreB 26679002

Expression and Regulation

Operons

• Genes: rodA
  Description: PubMed

  Sigma factors

  • SigM: sigma factor, PubMed, in SigM regulon

Biological materials

Mutant

• xylose-inducible CRISPRi knockdown mutant BEC38120 is available from the BGSC

Labs working on this gene/protein

• Charles Moran, Emory University, NC, USA homepage
• David Rudner, Harvard Medical School, MA, USA homepage

References

Reviews

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Original Publications

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